In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1, 2, 4-triazolo [1,5-a] pyrimidine Cu(II) complexes

Mendez-Arriaga, J. M.; Oyarzabal, I.; Escolano, G.; Rodriguez-Dieguez, A.; Sanchez-Moreno, M.; Salas, J. M.

VL / 180 - BP / 26 - EP / 32
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a] pyrimidine (7atp) and Cu (II) salts. Crystal structures of (Cu-2(mu-7atp)(4)Cl-2]Cl-2 center dot 4H(2)O(1) and [Cu-2(mu-7atp)(4)(H2O)(2)](NO3)(4)center dot H2O (2) have been studied by X-ray diffraction methods and characterized by spectroscopic and thermal analysis. Magnetic studies of these dinuclear complexes have revealed the existence of moderate antiferromagnetic interactions between the copper ions, with J values of - 91.2 and - 96.1 cm(-1) respectively. It must be highlighted that the antiparasitic activity of these new complexes has been studied in vitro against three different strains of leishmania spp. and Trypanosoma cruzi, showing a higher efficacy than the 7atp ligand and the reference commercial drugs.

Access level